Best Leaky Gut Supplements: Buy Natural Gut Healing Products

The research on how to heal a leaky gut naturally is on the tip of everyone's mental tongue who has come across the coin term ‘leaky gut syndrome'. Due to the inherent complexity of learning about how to repair leaky gut through the use of natural leaky gut supplementation, this guide was meant to simplify by adding clarity to one of the emerging trends in the health and wellness space.

Leaky gut is a digestive condition where bacteria and toxins are offered the opportunity to “leak” or permeate through the intestinal wall and into the bloodstream. Believed to be associated with factors ranging from alcohol consumption and select painkillers to poor diet and a possible genetic predisposition, this is one that warrants further care. Why? In all truth, a leaky gut can lead to digestive discomfort, exhaustion, headaches, cognitive fog and poor skin health to name the least.

As people continue to seek feasible solutions, one hindrance that is likely to come up, is trying to differentiate the best of the best. Seeing that the supplements industry is saturated as it is, our team recently did all the dirty work! Precisely, much of our top picks align with those shared by other research efforts found online, with a few shifts and more details added to each leaky gut formula.

With so many available options to choose from, this list of the best leaky gut supplements is meant to give a viewpoint about why these natural gut healing formulas are a cut above the rest in terms of purity, potency and overall quality. In order to buy the top leaky gut repairing products on the market, it helps to know what is out there and see a side by side (in this case scroll by scroll) comparison of how all of the best formulas stack up to one another as a whole.

Top 10 Leaky Gut Supplements that Take the Crown

In going over the similarities and differences, weighing the pros and cons and some intense reflection, leaky gut supplements that set the bar high within the industry, at least for 2020, are as follows:

  • Bio Complete 3 by Gundry MD
  • GutMD by 1MD
  • Gut Reg by BioTRUST
  • Leaky Gut Defense by Pure Therapro Rx
  • Leaky Gut Revive by Amy Myers MD
  • Morning Complete by ActivatedYou
  • Multi-GI 5 by Unify Health Labs
  • Peak BioBoost by Peak Biome
  • Total Restore by Gundry MD
  • Viscera-3 by SANE

The ranking system applied to the best leaky gut supplement ratings was determined on a number of factors elaborated on after reviewing the list. Any one of these supplements out of the dozens and dozens of off-brand options out there to choose from stand out from the crowd and provide the most leaky gut healing and repairing value, along with giving the most bang for the buck. These are the leaky gut solutions worthy of a strong look into healing the stomach's gut lining and whole ecosystem through the use of targeted formulas for gut health and digestive function.

Unleashing the Potential of the Top 10:

Out of the dozens and dozens of potentially high quality probiotic gut health formulas to choose from, only the following ten made the final cut into this exclusive list of leaky gut supplements worthy of their probiotic strains or a number of other deciding factors outlined below. Here are the best leaky gut supplements to buy right now:

Bio Complete 3

Company: Gundry MD

30 servings: $49.99 USD

Bio Complete 3 is a dietary supplement that aims to neutralize the effects of leaky gut. Created by Gundry MD, this solution was approached by considering damages typically caused by microscopic endotoxins. As stated on the official website, the team not only focused on delivering a simple formula, but one that is also free of artificial sweeteners and/or added sugars and lectin.

A factor that stood out while looking further into Bio Complete 3 is that it has been formulated by a person of authority, namely, Dr. Steven Gundry MD. He remains one of the most celebrated pediatric heart surgeons in the world with over 30 years of experience. Considering that he appreciates all-natural solutions, has an eye for validated research and stands by everything he voices in regard to supplements, confidence should be the least of one’s worries.

Speaking of the entirety of Bio Complete 3, the “3” stands for three particular ingredients including 1000mg of CoreBiome™, 200mg Sunfiber® and 16mg of ProDURA® (or equivalently, 2 billion CFU). Clearly, each component has been patented, which implies possible clinical studies and lab testing to name the least.

For more information on Bio Complete 3 by Gundry MD, visit here


Company: 1MD

30 servings: $41.99 USD

GutMD is a dietary supplement that is intended to improve gut lining integrity, immunity, gastrointestinal movement and nutrients absorption among others. Many of the features found in this supplement resemble that of Bio Complete 3.

For starters, 1MD GutMD is doctor-formulated by gastroenterologist, Dr. David Kahana. Throughout his career, he claims to have witnessed “degradation and malfunction of the intestinal lining.” This led the expert to conceptualize this formula, which he insists was “designed to boost the health and function of the intestinal lining.”

Another common feature is that Dr. David Kahana stuck by the “simple is sweet” route, with emphasis placed on four clinically tested ingredients: 1500mg of L-Glutamine, 250mg of CARE4U®, 150mg of Gutgard® and 60mg of Fibregum™. Finally, the two deliver an ample concentration that actually might be a significant difference. Given its overall strength, individuals are surely getting something worth every single penny.

For more information on GutMD by 1MD, visit here

Gut Reg

Company: BioTRUST

30 servings: $49 USD

Gut Reg has been formulated to provide nutritional support for bettered and fortified gut lining. Addressing the health of one’s gut lining is trusted to give rise to a possibly healthy immune system, digestive function, mood and gut permeability levels to name a few. As witnessed in the Gut Reg formula, all of the ingredients have been scientifically studied to some extent (i.e. clinical trials), ultimately, minimizing room for doubt and/or lack of confidence.

Simplicity is becoming a common trend thus far, as Gut Reg comprises 15mg of Zinc, 500mg of L-Glutamine, 250mg of Ginger Extract and 75mg of Zinc-L-Carnosine. Although it is not doctor formulated, BioTRUST was founded by two individuals who have a strong reputation as a certified fitness personality and nutritionist and supplement expert respectively. The duo’s interest in biology and nutrition alone says a lot about the brand, along with their ongoing mission to give back to the community through knowledge.

For more information on Gut Reg by BioTRUST, visit here

Leaky Gut Revive

Company: Amy Myers MD

30 servings: $44.97 USD

Leaky Gut Revive has been formulated to nourish gut cells, restore the gut’s normal mucosal lining, relax the stomach and intestinal lining and promote healthy gut microflora. These benefits are deemed attainable due to its formula, which showcases ingredients such as 3g of L-Glutamine, and a combined 2.75g of Arabinogalactan, Marshmallow Root Powder, Deglycyrrhizinated Licorice Root, Slippery Elm Bark Powder, and Aloe vera.

In comparison to the previous formulas, Leaky Gut Revive may come across as being somewhat condensed. However, according to NYT bestselling author and functional medicine physician, Dr. Amy Myers, each ingredient plays a significant role in stimulating gut cells to regenerate all while minimizing inflammation.

Amusingly, Dr. Amy Myers is very transparent when it comes to educating consumers on her products. For each one, a video describing the basics of a particular health condition and how her solutions might help are provided. In fact, to get closer to consumers, she has since uploaded her resume and certifications! There are also plenty of positive Leaky Gut Revive reviews out there expressing feedback about Dr. Amy Myers leaky gut supplement.

For more information on Leaky Gut Revive by Amy Myers MD, visit here

Peak BioBoost

Company: Peak Biome

30 servings: $49.95 USD

Peak BioBoost is a dietary supplement consisting of a unique blend of prebiotics. Peak Biome believes that enhancing the gut flora should be the first step to healing the gut lining. This, in their viewpoint, starts with increasing prebiotics, as they serve as nutrition for good bacteria.

Some of the benefits that might result from taking Peak Biome's Peak BioBoost include reduced leaky gut, and boosted immunity. These are deemed nearly impossible if it weren’t for Acacia Gum, Fructooligosaccharide, Inulin and XOX (total of 8g per serving) and Magnesium Citrate (200mg per serving).

What is somewhat puzzling to see is the use of magnesium citrate, which is a saline laxative. When used extensively, it might create dependencies, and unwanted bowel-related concerns. Luckily, the team has minimized the concentration, making it less damaging than the average saline laxative. Finally, Peak BioBoost is advertised as one of the best prebiotic fiber supplements available for being doctor-formulated, where Peak Biome focuses its effort on a convenient blend that helps support healthy digestion, promotes bowel movement regularity and can even boost metabolism and curb cravings.

For more information on Peak BioBoost by Peak Biome, visit here

Morning Complete

Company: ActivatedYou

30 servings: $49 USD

Morning Complete is trusted to reduce bloat, gas and other digestive issues. In addition, it is meant to deliver a selection of ingredients that carry impressive nutritional value. This is probably the first supplement to approach gut-related issues differently in ActivatedYou Morning Complete formula that comes complete with green superfoods too.

To be more precise, each serving contains prebiotic and fiber, green superfoods, metabolic enhancing, antioxidants, sugar balancing, adaptogens, cellular function and liver support and probiotic blends. Evidently, that many blends make Morning Complete quite extensive. Who can forget the fact that the team approached the issue by considering herbs, which is not entirely conventional!

A point that needs to be made here is that Morning Complete somewhat strays away from the aforementioned supplements, especially when it comes to facets like “clinically-proven ingredients” and “doctor-formulated”. Then, why did it make the cut? ActivatedYou™ is a brand known for its efforts in purity and safety, namely through rigorous and independent third-party testings.

For more information on Morning Complete by ActivatedYou, visit here

Leaky Gut Defense

Company: Pure Therapro Rx

30 servings: $35 USD

Up next on our list is Leaky Gut Defense, a solution that is expected to amplify one’s gastrointestinal and digestive support. In addition, this supplement can bring comfort to those who have struggled with food allergies and sensitivities and irregularities in bowel movement.

Made in such a way that it can easily blend with any beverage base, Pure Therapro Rx decided to choose not one, but five ingredients, all proclaimed as being “patented, clinically-proven, free of GMOs and free of common allergens.” Specifically, each serving reflects 3g of L-Glutamine, 2g of Arabinogalactan, 500mg of Deglycyrrhizinated Licorice, 100mg of Aloe vera and Monk Fruit as the choice of sweetener.

Speaking of sweetness, most leaky gut supplements supposedly contain artificial sweeteners, which is reasoned as having drastic effects. Pure Therapro Rx’s decision to go with monk fruit instead rested in its ability to reduce oxidative stress, its antioxidant and anti-inflammatory effects on the body and the FDA’s “generally recognized as safe” certification.

Though this respective brand is only available through Amazon, the team affirm that reflect “Practitioner Referred. Pharmaceutical Grade. NSF/GMP Certified. USA Made. Clinically Studied and Meticulously Sourced Ingredients. Direct to Consumer Pricing.”

For more information on Leaky Gut Defense by Pure Therapro Rx, visit here

Multi-GI 5

Company: Unify Health Labs

30 servings: $69.95 USD

Multi-GI 5 was founded on the fundamental role our gut plays in boosting cognition and energy levels, controlling gas, bloating, and irregularity, and combating food cravings among others. A similar but less extensive approach was taken here, as the team at Unify Health Labs insists that all three; prebiotic, probiotic and gastrointestinal (GI) blends are equally needed.

That said, many of the ingredients found under the GI blend clearly resonates with others found in our list. In particular, the 433mg GI blend combines L-Glutamine, Zinc-Carnosine Complex, ProDURA and Deglycyrrhizinated Licorice Root Extract. Others found in this category are Magnesium, BioPerine, and Berberine.

As for the “5” in its name, it is meant to signify the core benefits of taking Multi-GI 5, which purportedly include healthy digestion, improved weight management, increased energy and a healthy GI lining.

Last but not least, American Idol judge and renowned musician and producer, Randy Jackson helped start Unify Health Labs. As someone who previously struggled with weight management goals, he is likely to understand what many consumers face today, which gives a personal touch to this brand.

For more information on Multi-GI 5 by Unify Health Labs, visit here

Total Restore

Company: Gundry MD

30 servings: $69.95 USD

Gundry MD houses not one but two leaky-gut healing supplements, the second one being, Total Restore. With emphasis placed on gut lining, and issues such as fatigue, digestive discomfort and weight issues, this supplement ties together 16 all-natural ingredients that might even go as far as supporting comfortable joints health and better managed food cravings.

Many of the ingredients found in Bio Complete 3 have made a reappearance in Total Restore, with others similar to Morning Complete and Leaky Gut Revive. Aside from the different ingredient profiles in both Bio Complete 3 and Total Restore, another major difference is that the former serves as the basis of gut support, while the latter focuses on the fine details, i.e. healing gut-related concerns from leaky gut and irritable bowel syndrome (IBS) to imbalanced gut bacteria. Lastly, Total Restore is offered at a much lower concentration than Bio Complete 3.

For more information on Total Restore by Gundry MD, visit here


Company: SANE Laboratories

30 servings: $47 USD

Viscera-3 is a post biotic dietary supplement. In fact, it is deemed a new “one-of-a-kind” gut health breakthrough that combines select molecules of short-chain fatty acids capable of triggering numerous healthy effects on the gut. Ingredients such as 1000mg of CoreBiome, 600mg of Pomegranate and SLIMGut Garden, 110 mg of Magnesium and 100mcg of Chromium are what allow consumers to fully experience benefits such as feeling light, seeing a surge in energy and smoother bowel movements to name the least.

According to SANE Laboratories, taking prebiotics or probiotics aren’t enough to eliminate leaky gut. This is because the root cause is allegedly not addressed, making them all go to waste. Hence, the route of retorting to postbiotics, which are becoming the next big thing in gut health-supporting supplements.

As for the company as a whole, the team follows one philosophy, i.e. the “SANESolution PHILOSOPHY”, which promotes food as something that should be enjoyed, and completely satisfied all while stimulating the body’s natural “fat-burning and blood-sugar balancing” potential. There are a lot of positive reviews about Viscera-3 online, as well as reports about the postbiotic clinical research formulation from SANE.

For more information on Viscera-3 by SANE Laboratories, visit here

The Customized Ranking System Focused On

With leaky gut supports flooding the supplements industry, individuals will have to step back and wonder whether quality out beats quantity of ingredients, and whether there is anything that will compromise safety in the long run. These were thoughts that were running in our heads as well. After some deliberation, we decided to focus on supplements that checked off seven crucial boxes.

First, we have scientifically proven ingredients. L-glutamine remains the top contender when it comes to healing a leaky gut, therefore, this was one that had to make it across no matter what. Following suit comes support from a person of authority. By person of authority, we mean someone who has knowledge on how the body works and what it is that occurs to the gut lining that leads to a leaky gut. As seen above, many of our picks sought for doctors’ and nutritionists’ formulas.

Third, the strength of each ingredient’s concentration was analyzed. This is not to say it is best, instead, we looked at companies that stuck by doses that reflect some of the conclusions made by scientific research. If the goal is to avoid any harm to one’s health, doses must be appropriately fitting as well.

From there, it was of utmost interest to see how the company approached leaky gut. Leaky gut is a health condition that many perceive as a one particular problem, but in all truth, it blends and lends a helping hand to other concerns. This factor will tell everyone the company’s thought process and whether or not the root cause was addressed to some extent.

Who can forget a company’s level of transparency?! Transparency as a factor can help to make informative decisions on various levels. It tells us something about the company, their reputation, their interest in helping consumers, labelling practices, effectiveness and value for price among other. Clearly, this factor is present in all of the aforementioned factors as well.

Finally, it was imperative that we go over the promoted benefits. This is another piece to the puzzle that helps to clear off bad players while highlighting the good. A common trend that one might have witnessed in this industry is that either a claim is exaggerated, or it is backed by science. Honesty is the best policy, and this is something that people need to live by, especially when it comes to supplements ingestion because it can dramatically alter one’s health!

Other factors that were welcomed as each supplement was presented to us include convenience, money-back guarantees and value for price – all of which were considered as bonuses. For the best leaky gut supplement today, click here to see the top rated, most compelling gut healing formula available right now.

The Story Science Has to Tell Regarding Leaky Gut-Healing Ingredients

As mentioned above, a scientifically proven ingredient was a big box that companies had to check off to make the cut. In order to fully understand the scientific narrative of leaky-gut healing ingredients, we decided to pick the top five that reappeared the most in our review. Below is a summary of what each one is, and the conclusions drawn by researchers up until this point:


Glutamine is a naturally occurring amino acid in the body. Created in the muscles, it eventually travels through the bloodstream, and tends to gut function, immune function and other processes. Interestingly, glutamine is perceived as a component that can support the entire body when presented with stress, inflammation and other harmful factors.

A 2015 review that studied research on glutamine and its contributions towards leaky gut healing concluded that “glutamine is an essential nutrient for gut and musical epithelial cell growth, differentiation, mucosal integrity and barrier function,” adding that there is “ample evidence to indicate that L-glutamine is the essential dietary supplement to help maintain mucosal integrity.”

A 2017 study that looked specifically at dose response of glutamine supplementation on GI permeability found that a relatively low dose has the potential to improve intestinal permeability after exercise. Intestinal permeability is indicative how smoothly things pass through the intestinal walls. If things are not flowing so smoothly and are stuck in a tight situation, the walls themselves start to lose traction. Having said all that, this study did not look at whether GI symptoms will have reduced.

Another point to be made here is that there is little evidence on whether this amino acid can help those with severe intestinal diseases. So, people in such a situation might have to retort to other treatment options recommended by their physicians.


Arabinogalactan is a plant-based chemical/fiber that has been used for medicinal purposes. In a 2016 study that looked at the effects of arabinogalactan on the gut barrier function found significant evidence that arabinogalactan alongside fructooligosaccharides (FOS) can “modulate the gut wall functionality” while decreasing pro-inflammatory cytokine (i.e. these are immunoregulatory cytokines that favor inflammation).

Physician of integrative and functional medicine, Dr. Raphael Kellman, M.D, noted in a post that arabinogalactans support immune function by decreasing inflammation. It supposedly also has the ability to decrease the body’s production of ammonia, which can help ease the intestines. Having prescribed the fiber to many of his patients, he insists that many started losing weight and believes that it can enhance friendly bacteria in the gut.

Dr. Amy Myers M.D stands by this ingredient. Here is her reasoning: “Probiotic bacteria ferment the arabinogalactan and produce fatty acids, such as butyrate, in the process. These fatty acids are incredibly beneficial to your gut and intestinal barrier!”

Deglycyrrhizinated Licorice

In a review conducted by the Health Line team, licorice supposedly possesses over 75 bioactive compounds, one of them being glycyrrhizin. As for the reason why deglycyrrhizinated licorice (DGL) seems to have been a popular pick is because of the potential it has in reducing inflammation and increasing mucus production. In further investigating the role of mucus, a 2013 review noted that it is vital for gastrointestinal tract protection. Unfortunately, evidence doesn’t suffice to make direct connections between DGL and leaky-gut healing.

Zinc-Carnosine Complex

As defined by Wikipedia, zinc carnosine is a mucosal protective chelate compound that evidently combines the likes of zinc and carnosine. In exploring studies on this matter, a 2007 study popped up. At the time the researchers were interested in evaluating the effect of Zinc-Carnosine Complex on “various gut injury and repair” models. They have since concluded that the complex can stabilize gut mucus.

This respective ingredient might also be presented in the form of PepZin Gi, which has been registered with the US-FDA, Australia’s TGA and Japan’s PMDA. In a place-controlled double-blind study with 299 patients. Of the 136 patients subjected to the PepZin GI group, 92% reported a moderate improvement or better on an improvement scale across symptoms such as “heartburn, tenderness, epigastric pain, diarrhea and constipation after 8 weeks.”

It has also been found to have effects on certain types of bad bacteria, which implies a potential balance in one’s GI environment and this as a result, might lead to a healthy mucosal lining. Finally, taking this particular complex is believed to prevent free radical damage, alcohol-induced damage and oxidative stress to gastric cells.


CoreBiome™ is a postbiotic in the form of short-chain fatty acids (SCFAS) or more specifically, tributyrin. A 2018 study aimed to investigate the effects of butyrate supplementation in the form of triglyceride tributyrin on immune responses has since concluded that it can reduce oxidative stress. Health Line did a comprehensive research piece on butyric acid (a type of SCFAS), which showed that in general, SCFAS can help treat irritable bowel syndrome, colon cancer, and insulin sensitivity.

Based on the analysis above, it is evident that picking supplements based on L-glutamine as the main ingredient might have not been the appropriate way to go about things. Though the amino acid is linked to a large extent, not all additional ingredients found have sufficient scientific backing. That said, it seems like each of the supplement’s doses contain higher concentrations of evidence-based ingredients, with relatively safe doses of those that require more. On this basis, one might not have to worry about being deprived of safety.

See the best rated solution for adding the vital healthy ingredients into the body's internal ecosystem to start repairing and healing leaky gut syndrome optimally.

Frequently Asked Questions (FAQS)

What is a leaky gut syndrome?

Harvard Health Publishing (HHP) defines leaky gut syndrome as a condition that is triggered by an “unhealthy gut lining [that] may have large cracks or holes.” It is furthered argued that such an event is surely to give room for “partially digested food, toxins, and bugs” to reap through the tissues and more. The reason why this is a problem is because it is likely to lead to increased inflammation, and imbalances in the gut flora and the digestive system.

What are common warning signs of leaky gut syndrome?

As per Healthline’s reporting, some of the most common warning signs/symptoms linked to leaky gut syndrome include bloating, food sensitivities, a list of digestive discomforts, poor skin health and exhaustion among others. If any of these symptoms persist, consumers are highly recommended to consult a physician.

How dangerous is it to be diagnosed with a leaky gut syndrome?

Existing studies have since established a close association between leaky gut syndrome and a selection of autoimmune diseases, chronic fatigue syndrome, arthritis, sleep disturbances and poor mental and joint health writes HHP.

Can a leaky gut be improved by making changes to one’s diet?

Based on Dr. Ruscio, DNM, DC, eating a diet filled with real, whole foods is usually preferred. This means anything that has been processed or containing artificial ingredients should be avoided. This will at least help to minimize inflammation in the body. Having said that, some of his top picks for those looking to create a meal plan include fresh veggies, roots and tubers, fermented veggies, fresh fruit, whole grains, healthy fats, wild fish, grass-fed meat and eggs, nuts and seeds, herbs and spices and cultured dairy products.

How does a leaky gut impact the immune system?

As previously mentioned, with a leaky gut, bacteria, undigested foods and other harmful toxins have the ability to enter the bloodstream. In doing so, the body starts to become inflamed, and continues to accumulate with time. Unfortunately, the immune system’s defense mechanism takes a hit, which makes it incapable of responding to inflammation or the presence of bacteria.

When is the best time to take leaky gut supplements?

Leaky gut supplements can be taken any time of the day. Dr Amy Meyers typically prefers to take them first thing in the morning with either a glass of water or with breakfast. On that note, she argues that it can be squeezed in between meals as one desires. Adding to the latter, picking a particular time of day might be something to consider, as consistency tends to lead to better results.

What are common side effects of leaky gut supplements?

With just about any supplement, side effects need to be thought of beforehand. In scavenging through a number of resources, consumers who have taken leaky gut supplements have reported short-lived diarrhea, constipation, bloating, exhaustion, headaches and poor cognitive function. These are deemed normal only because the body needs to adapt to newcomers. If for some reason individuals are faced with severe health implications, the leaky gut supplement should be halted, and help should be sought-for.

Are probiotics effective at treating leaky gut?

In general, probiotics aren’t only advertised as supporting good bacteria in the gut, but also as a possible solution for treating a leaky gut, therefore, it seems reasonable to consider them as being effective. In fact, some of our picks carry different sources of prebiotics and probiotics.

Are leaky gut supplements safe for pregnant women, breastfeeding mothers and/or children?

It might be best for pregnant women, breastfeeding mothers and/or children to refrain from taking leaky gut supplements. Given the presence of butyric acid (i.e. a type of short-chain fatty acid), it is safer to wait it out. Another possible reason why such supplements should be avoided is due to the lack of studies (i.e. for certain ingredients), especially during such a sensitive time. If interest persists, individuals are heavily recommended to sit down and discuss matters with their respective health practitioners.

Final Thoughts

Leaky gut syndrome remains a hot topic of discussion, as it can easily deteriorate other regions of the body. When consumers start to see some of its notable symptoms, they should instantly seek help so that the issue of inflammation can be brought down to a minimum. As for treatments, again, a physician’s opinion is number one, followed by additional supports such as leaky gut supplements. It is important to note that such supplements are not meant to treat or cure a condition, but instead ease symptoms and act as a driving force towards a healthier gut and gut lining.

As seen above, our top ten picks have been refined by considering numerous factors, and this approach can be used for just about any solution. For now, they remain the best when it comes to revamping gut health, but individuals are encouraged to keep an eye out for market newcomers. The beauty of these supplements is that they all tend to many problems through different lenses, therefore, one’s own health condition and goals need to be evaluated prior to making a purchase.
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